Obsidian Entertainment will release the first story expansion for The Outer Worlds 2 in December. The expansion, titled Side Effects Guaranteed, is the first of a two-part DLC. Players will hunt for a cure to "explosive cell death" in the expansion.

The studio released The Outer Worlds 2 about a year ago. Since then, Obsidian lost staff during Microsoft's mass layoffs and shifted focus to developing a new Fallout game as part of Bethesda's operations within Xbox. The two-part expansion arrives under these changed circumstances.